Manchester United boss Louis van Gaal says keeper David De Gea is not "capable" of playing in Saturday's season opener against Tottenham.
De Gea, 24, reportedly wants to move to Real Madrid with speculation over his future persisting all summer.
"We've observed him in training and matches and he's not the David De Gea of last year," said Van Gaal.
New signing Sergio Romero, 28, Anders Lindegaard, 31, or Sam Johnstone, 22, could replace De Gea.
Lindegaard and Johnstone travelled on the club's summer US tour, but neither played for United last season. Lindegaard did not feature once in the previous campaign, while Johnstone has yet to make his United debut.
United also have Victor Valdes, but the 33-year-old Spaniard has been made available for transfer after Van Gaal claimed he "refused to play" in the reserves.
"De Gea tries and does his utmost best, but it's a difficult situation," added Van Gaal.
"Now we have to play our first match and I want players who can focus only on the match and he is not capable to do that.
"He shall not play."
De Gea has made 175 appearances since joining United from Real's city rivals Atletico Madrid in 2011.
United are believed to be holding out for a deal that includes Real defender Sergio Ramos coming to Old Trafford.
Source : BBC Sport
